This gene encodes a large protein that contains a helix-loop-helix domain and a polyglutamine region. A deletion in the polyglutamine region was associated with risk for thyroid carcinoma. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for USF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,085,739–112,087,192 | 1610.2 kb | Distal (>10kb) Multiome HiCAR | 690 | |
| chr3:113,441,051–113,442,064 | 255.1 kb | Distal (>10kb) Multiome | 198 | |
| chr3:113,514,383–113,515,648 | 181.5 kb | Distal (>10kb) Multiome | 705 | |
| chr3:113,532,401–113,533,734 | 163.5 kb | Distal (>10kb) Multiome | 388 | |
| chr3:113,695,756–113,697,740 | 71 bp | At TSS Multiome | 796 | |
| chr3:113,698,938–113,699,553 | 2.3 kb | Proximal (<10kb) | 172 | |
| chr3:113,744,989–113,747,921 | 48.6 kb | Distal (>10kb) Multiome | 1061 | |
| chr3:113,838,330–113,839,358 | 142.2 kb | Distal (>10kb) Multiome | 588 | |
| chr3:113,947,254–113,948,963 | 251.2 kb | Distal (>10kb) Multiome | 685 |
Genomic view of the USF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.