This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for URI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = URI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of URI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:29,665,021–29,667,200 | 276.9 kb | Distal (>10kb) Multiome | 621 | |
| chr19:29,714,800–29,715,683 | 227.0 kb | Distal (>10kb) Multiome | 726 | |
| chr19:29,724,045–29,724,626 | 217.9 kb | Distal (>10kb) Multiome | 189 | |
| chr19:29,759,946–29,760,434 | 182.0 kb | Distal (>10kb) Multiome | 502 | |
| chr19:29,811,175–29,812,847 | 130.5 kb | Distal (>10kb) Multiome | 705 | |
| chr19:29,843,949–29,845,909 | 97.3 kb | Distal (>10kb) Multiome | 804 | |
| chr19:29,872,251–29,872,744 | 69.9 kb | Distal (>10kb) Multiome | 90 | |
| chr19:29,872,961–29,874,087 | 68.6 kb | Distal (>10kb) Multiome | 469 | |
| chr19:29,941,860–29,942,984 | 41 bp | At TSS Multiome | 766 |
Genomic view of the URI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.