Predicted to be involved in regulation of signal transduction by p53 class mediator and ribosome biogenesis. Located in aggresome; midbody; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for URB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = URB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of URB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:229,342,012–229,343,421 | 283.6 kb | Distal (>10kb) Multiome | 829 | |
| chr1:229,507,825–229,508,800 | 117.9 kb | Distal (>10kb) Multiome | 885 | |
| chr1:229,557,924–229,559,481 | 67.3 kb | Distal (>10kb) Multiome | 985 | |
| chr1:229,625,075–229,626,774 | 190 bp | At TSS Multiome | 894 | |
| chr1:230,641,860–230,643,036 | 1016.1 kb | Distal (>10kb) Multiome HiCAR | 985 |
Genomic view of the URB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.