Enables ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial inner membrane. Implicated in mitochondrial complex III deficiency. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for UQCRH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCRH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCRH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:46,131,887–46,133,691 | 170.8 kb | Distal (>10kb) Multiome | 1126 | |
| chr1:46,198,117–46,198,832 | 105.2 kb | Distal (>10kb) Multiome | 646 | |
| chr1:46,203,021–46,203,710 | 100.3 kb | Distal (>10kb) Multiome | 394 | |
| chr1:46,246,904–46,248,623 | 56.2 kb | Distal (>10kb) Multiome | 923 | |
| chr1:46,254,338–46,255,513 | 49.0 kb | Distal (>10kb) Multiome | 39 | |
| chr1:46,301,645–46,303,965 | 245 bp | At TSS Multiome | 1035 | |
| chr1:46,340,061–46,341,413 | 37.0 kb | Distal (>10kb) Multiome | 967 | |
| chr1:46,394,021–46,394,849 | 90.7 kb | Distal (>10kb) Multiome | 795 | |
| chr1:46,401,942–46,402,392 | 98.5 kb | Distal (>10kb) Multiome | 511 | |
| chr1:46,406,082–46,407,120 | 102.8 kb | Distal (>10kb) Multiome | 299 | |
| chr1:46,442,171–46,443,351 | 139.0 kb | Distal (>10kb) Multiome | 649 | |
| chr1:46,448,113–46,448,679 | 144.8 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,466,221–46,467,348 | 163.0 kb | Distal (>10kb) Multiome | 398 | |
| chr1:46,489,045–46,490,312 | 186.0 kb | Distal (>10kb) Multiome | 381 | |
| chr1:46,516,974–46,517,563 | 213.5 kb | Distal (>10kb) Multiome | 328 | |
| chr1:46,525,135–46,525,776 | 221.7 kb | Distal (>10kb) Multiome | 169 | |
| chr1:46,526,636–46,527,311 | 223.3 kb | Distal (>10kb) Multiome | 225 | |
| chr1:46,532,918–46,533,689 | 229.5 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the UQCRH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.