The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for UQCRC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCRC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCRC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:21,952,487–21,953,795 | 209 bp | At TSS Multiome | 1014 | |
| chr16:22,007,549–22,008,682 | 54.7 kb | Distal (>10kb) Multiome | 685 | |
| chr16:22,189,506–22,191,692 | 237.5 kb | Distal (>10kb) Multiome | 989 | |
| chr16:22,195,474–22,196,347 | 242.5 kb | Distal (>10kb) Multiome | 886 | |
| chr16:22,205,924–22,206,847 | 252.9 kb | Distal (>10kb) Multiome | 1038 |
Genomic view of the UQCRC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.