This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for UQCRB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCRB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCRB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:95,959,886–95,961,052 | 275.2 kb | Distal (>10kb) Multiome | 112 | |
| chr8:96,041,590–96,042,241 | 193.6 kb | Distal (>10kb) Multiome | 86 | |
| chr8:96,132,837–96,133,612 | 102.4 kb | Distal (>10kb) Multiome | 251 | |
| chr8:96,144,359–96,146,213 | 90.5 kb | Distal (>10kb) Multiome | 434 | |
| chr8:96,153,788–96,155,013 | 81.3 kb | Distal (>10kb) Multiome | 147 | |
| chr8:96,160,183–96,162,079 | 74.5 kb | Distal (>10kb) Multiome | 394 | |
| chr8:96,227,327–96,227,536 | 8.0 kb | Proximal (<10kb) | 49 | |
| chr8:96,234,663–96,234,975 | 570 bp | At TSS | 205 | |
| chr8:96,235,143–96,236,137 | 58 bp | At TSS Multiome | 677 | |
| chr8:96,261,159–96,263,004 | 26.2 kb | Distal (>10kb) Multiome | 1100 | |
| chr8:96,281,343–96,281,988 | 45.8 kb | Distal (>10kb) Multiome | 137 | |
| chr8:96,327,549–96,328,440 | 92.5 kb | Distal (>10kb) Multiome | 453 | |
| chr8:96,493,060–96,495,549 | 258.2 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the UQCRB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.