UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for UQCR10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCR10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCR10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,470,132–29,470,844 | 296.9 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 286.3 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 213.6 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 186.3 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 163.9 kb | Distal (>10kb) Multiome | 803 | |
| chr22:29,766,399–29,767,654 | 299 bp | At TSS Multiome | 837 | |
| chr22:29,837,985–29,838,559 | 71.0 kb | Distal (>10kb) Multiome | 690 | |
| chr22:29,882,926–29,883,914 | 115.8 kb | Distal (>10kb) Multiome | 628 |
Genomic view of the UQCR10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.