This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for UNKL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNKL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNKL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,152,124–1,154,512 | 261.8 kb | Distal (>10kb) Multiome | 341 | |
| chr16:1,300,823–1,301,358 | 113.6 kb | Distal (>10kb) Multiome | 419 | |
| chr16:1,308,686–1,309,923 | 105.5 kb | Distal (>10kb) Multiome | 953 | |
| chr16:1,331,603–1,332,817 | 82.7 kb | Distal (>10kb) Multiome | 492 | |
| chr16:1,333,312–1,334,056 | 81.1 kb | Distal (>10kb) Multiome | 271 | |
| chr16:1,342,604–1,343,805 | 71.5 kb | Distal (>10kb) Multiome | 560 | |
| chr16:1,351,418–1,352,242 | 62.8 kb | Distal (>10kb) Multiome | 733 | |
| chr16:1,378,844–1,380,439 | 34.9 kb | Distal (>10kb) Multiome | 782 | |
| chr16:1,408,010–1,408,819 | 6.4 kb | Proximal (<10kb) Multiome | 546 | |
| chr16:1,413,643–1,415,278 | 77 bp | At TSS Multiome | 661 | |
| chr16:1,420,269–1,421,402 | 6.2 kb | Proximal (<10kb) Multiome | 897 | |
| chr16:1,474,566–1,475,411 | 60.4 kb | Distal (>10kb) Multiome | 915 | |
| chr16:1,492,797–1,493,962 | 78.6 kb | Distal (>10kb) Multiome | 710 | |
| chr16:1,610,035–1,611,264 | 195.9 kb | Distal (>10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 197.5 kb | Distal (>10kb) Multiome | 718 | |
| chr16:1,677,899–1,679,024 | 263.5 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 291.4 kb | Distal (>10kb) Multiome | 933 |
Genomic view of the UNKL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.