Enables mRNA CDS binding activity. Involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UNK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,514,425–75,517,171 | 269.2 kb | Distal (>10kb) Multiome | 1158 | |
| chr17:75,524,764–75,527,160 | 259.3 kb | Distal (>10kb) Multiome | 951 | |
| chr17:75,549,465–75,550,388 | 234.9 kb | Distal (>10kb) Multiome | 602 | |
| chr17:75,587,697–75,590,735 | 195.5 kb | Distal (>10kb) Multiome | 744 | |
| chr17:75,633,694–75,634,328 | 150.8 kb | Distal (>10kb) Multiome | 559 | |
| chr17:75,666,763–75,667,767 | 117.6 kb | Distal (>10kb) Multiome | 783 | |
| chr17:75,720,933–75,721,693 | 63.5 kb | Distal (>10kb) Multiome | 509 | |
| chr17:75,753,534–75,754,285 | 31.0 kb | Distal (>10kb) Multiome | 699 | |
| chr17:75,764,621–75,765,674 | 19.7 kb | Distal (>10kb) Multiome | 769 | |
| chr17:75,778,786–75,780,191 | 5.0 kb | Proximal (<10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 13 bp | At TSS Multiome | 1176 | |
| chr17:75,827,420–75,828,293 | 43.0 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 45.5 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 48.3 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 60.5 kb | Distal (>10kb) Multiome | 703 | |
| chr17:75,854,955–75,856,363 | 70.7 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 93.2 kb | Distal (>10kb) Multiome | 884 | |
| chr17:75,896,392–75,897,754 | 112.1 kb | Distal (>10kb) Multiome | 831 | |
| chr17:75,904,371–75,905,532 | 120.2 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:75,940,734–75,941,471 | 156.3 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 194.5 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 199.0 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 229.6 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 244.8 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 287.7 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 289.8 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the UNK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.