This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for UNC5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,887,437–70,888,780 | 324.2 kb | Distal (>10kb) Multiome HiCAR | 728 | |
| chr10:71,209,068–71,209,348 | 3.2 kb | Proximal (<10kb) | 446 | |
| chr10:71,212,161–71,213,632 | 7 bp | At TSS Multiome | 581 | |
| chr10:71,217,288–71,217,646 | 4.7 kb | Proximal (<10kb) | 218 | |
| chr10:71,217,754–71,218,367 | 5.2 kb | Proximal (<10kb) | 257 | |
| chr10:71,318,890–71,319,987 | 106.8 kb | Distal (>10kb) Multiome | 790 | |
| chr10:71,377,217–71,377,664 | 164.9 kb | Distal (>10kb) Multiome | 744 | |
| chr10:71,396,097–71,397,631 | 184.0 kb | Distal (>10kb) Multiome | 349 |
Genomic view of the UNC5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.