This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UNC13B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC13B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC13B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,957,639–34,958,516 | 203.9 kb | Distal (>10kb) Multiome | 211 | |
| chr9:34,988,494–34,990,699 | 172.4 kb | Distal (>10kb) Multiome | 703 | |
| chr9:35,026,200–35,027,109 | 135.1 kb | Distal (>10kb) Multiome | 187 | |
| chr9:35,071,688–35,073,229 | 90.0 kb | Distal (>10kb) Multiome | 975 | |
| chr9:35,079,435–35,080,247 | 82.1 kb | Distal (>10kb) Multiome | 773 | |
| chr9:35,095,921–35,096,910 | 65.5 kb | Distal (>10kb) Multiome | 960 | |
| chr9:35,102,684–35,103,800 | 58.7 kb | Distal (>10kb) Multiome | 886 | |
| chr9:35,110,953–35,112,122 | 50.3 kb | Distal (>10kb) Multiome | 527 | |
| chr9:35,113,899–35,117,460 | 44.7 kb | Distal (>10kb) Multiome | 840 | |
| chr9:35,156,365–35,156,622 | 5.4 kb | Proximal (<10kb) | 23 | |
| chr9:35,161,521–35,162,743 | 1 bp | At TSS Multiome | 827 | |
| chr9:35,406,111–35,407,050 | 244.7 kb | Distal (>10kb) Multiome | 145 | |
| chr9:35,424,217–35,425,184 | 262.7 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the UNC13B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.