This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for UNC13A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC13A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC13A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,390,414–17,391,521 | 297.2 kb | Distal (>10kb) Multiome | 615 | |
| chr19:17,394,998–17,395,433 | 293.1 kb | Distal (>10kb) Multiome | 403 | |
| chr19:17,398,863–17,399,537 | 289.1 kb | Distal (>10kb) Multiome | 132 | |
| chr19:17,403,087–17,404,355 | 284.8 kb | Distal (>10kb) Multiome | 211 | |
| chr19:17,419,503–17,420,821 | 268.4 kb | Distal (>10kb) Multiome | 869 | |
| chr19:17,424,865–17,425,411 | 263.2 kb | Distal (>10kb) Multiome | 328 | |
| chr19:17,448,174–17,448,841 | 239.7 kb | Distal (>10kb) Multiome | 392 | |
| chr19:17,468,858–17,470,905 | 218.2 kb | Distal (>10kb) Multiome | 743 | |
| chr19:17,488,739–17,489,689 | 199.2 kb | Distal (>10kb) Multiome | 381 | |
| chr19:17,511,113–17,512,592 | 176.8 kb | Distal (>10kb) Multiome | 1021 | |
| chr19:17,538,878–17,540,353 | 148.6 kb | Distal (>10kb) Multiome | 725 | |
| chr19:17,555,194–17,556,523 | 132.8 kb | Distal (>10kb) Multiome | 713 | |
| chr19:17,576,463–17,577,455 | 111.4 kb | Distal (>10kb) Multiome | 236 | |
| chr19:17,579,580–17,580,242 | 108.3 kb | Distal (>10kb) Multiome | 281 | |
| chr19:17,605,468–17,607,009 | 82.2 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:17,686,280–17,688,656 | 1.6 kb | Proximal (<10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 31.1 kb | Distal (>10kb) Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 59.3 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 74.3 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 90.0 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 106.8 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 142.6 kb | Distal (>10kb) Multiome | 466 | |
| chr19:17,841,205–17,843,221 | 153.7 kb | Distal (>10kb) Multiome | 545 | |
| chr19:17,847,546–17,848,187 | 159.4 kb | Distal (>10kb) Multiome | 437 | |
| chr19:17,859,472–17,860,202 | 171.4 kb | Distal (>10kb) Multiome | 822 | |
| chr19:17,873,769–17,874,763 | 185.9 kb | Distal (>10kb) Multiome | 303 | |
| chr19:17,931,700–17,932,248 | 243.5 kb | Distal (>10kb) Multiome | 136 | |
| chr19:17,932,373–17,933,607 | 244.4 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,942,639–17,943,673 | 255.0 kb | Distal (>10kb) Multiome | 302 | |
| chr19:17,947,203–17,950,613 | 259.7 kb | Distal (>10kb) Multiome | 639 | |
| chr19:17,951,201–17,952,652 | 263.9 kb | Distal (>10kb) Multiome | 237 | |
| chr19:17,966,756–17,967,353 | 278.7 kb | Distal (>10kb) Multiome | 127 |
Genomic view of the UNC13A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.