Predicted to enable calcium ion binding activity and peptidase inhibitor activity. Predicted to act upstream of or within several processes, including cellular response to gonadotropin-releasing hormone; regulation of granulosa cell apoptotic process; and regulation of ovarian follicle development. Predicted to be located in cytoplasm; external side of plasma membrane; and extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UMODL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UMODL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UMODL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:41,878,502–41,879,847 | 248.5 kb | Distal (>10kb) Multiome HiCAR | 630 | |
| chr21:41,953,094–41,954,549 | 173.6 kb | Distal (>10kb) Multiome | 667 | |
| chr21:42,009,116–42,011,396 | 117.4 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr21:42,107,454–42,108,282 | 19.7 kb | Distal (>10kb) Multiome | 336 | |
| chr21:42,117,534–42,117,716 | 10.0 kb | Proximal (<10kb) | 219 | |
| chr21:42,218,772–42,219,352 | 91.4 kb | Distal (>10kb) Multiome | 258 | |
| chr21:42,234,400–42,235,305 | 107.2 kb | Distal (>10kb) Multiome | 427 |
Genomic view of the UMODL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.