ULK3
unc-51 like kinase 3 | DKFZP434C131, FLJ90566

Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 30 terms
ATP binding (GO:0005524)autophagosome (GO:0005776)autophagosome assembly (GO:0000045)autophagy (GO:0006914)autophagy (GO:0006914)cellular senescence (GO:0090398)ciliary tip (GO:0097542)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)fibroblast activation (GO:0072537)mitophagy (GO:0000423)phagophore assembly site (GO:0000407)phagophore assembly site (GO:0000407)phagophore assembly site membrane (GO:0034045)piecemeal microautophagy of the nucleus (GO:0034727)positive regulation of smoothened signaling pathway (GO:0045880)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of autophagy (GO:0010506)response to starvation (GO:0042594)reticulophagy (GO:0061709)smoothened signaling pathway (GO:0007224)
Expression (TPM)
ULK3 — as a Regulated Gene

TFs regulating ULK3 0 TFs

Transcription factors with Perturb-seq knockdown data for ULK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ULK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ULK3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ULK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr15:74,598,102–74,598,966 244.7 kb Distal (>10kb) Multiome 689
chr15:74,614,343–74,616,348 227.4 kb Distal (>10kb) Multiome 1019
chr15:74,695,758–74,696,387 147.1 kb Distal (>10kb) Multiome 775
chr15:74,720,336–74,720,840 122.5 kb Distal (>10kb) Multiome 16
chr15:74,725,773–74,726,537 117.0 kb Distal (>10kb) Multiome 607
chr15:74,759,107–74,760,837 82.8 kb Distal (>10kb) Multiome 637
chr15:74,761,837–74,762,260 81.0 kb Distal (>10kb) Multiome 34
chr15:74,770,975–74,771,578 71.9 kb Distal (>10kb) Multiome 485
chr15:74,781,439–74,783,648 61.1 kb Distal (>10kb) Multiome 679
chr15:74,835,353–74,835,706 7.4 kb Proximal (<10kb) 264
chr15:74,842,412–74,843,723 145 bp At TSS Multiome 879
chr15:74,872,771–74,874,092 30.1 kb Distal (>10kb) Multiome 758
chr15:74,889,894–74,890,629 46.9 kb Distal (>10kb) Multiome HiCAR 816
chr15:74,905,926–74,907,376 63.7 kb Distal (>10kb) Multiome 743
chr15:74,937,494–74,938,710 94.9 kb Distal (>10kb) Multiome 998
chr15:74,950,147–74,950,911 107.5 kb Distal (>10kb) Multiome 326
chr15:74,954,536–74,955,001 111.6 kb Distal (>10kb) Multiome 348
chr15:74,955,873–74,957,720 113.7 kb Distal (>10kb) Multiome 776
chr15:74,958,363–74,959,586 115.4 kb Distal (>10kb) Multiome 282
chr15:74,995,116–74,996,280 152.4 kb Distal (>10kb) Multiome 825
chr15:75,023,365–75,023,895 180.4 kb Distal (>10kb) Multiome 822
chr15:75,140,133–75,140,707 297.2 kb Distal (>10kb) Multiome 536

Genome Browser

Genomic view of the ULK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr15:74,588,102 – 75,150,707
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact