This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for ULK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ULK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ULK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,579,724–19,580,220 | 288.1 kb | Distal (>10kb) Multiome | 101 | |
| chr17:19,645,969–19,646,517 | 221.8 kb | Distal (>10kb) Multiome | 116 | |
| chr17:19,647,149–19,649,280 | 220.5 kb | Distal (>10kb) Multiome | 1126 | |
| chr17:19,744,539–19,745,417 | 122.9 kb | Distal (>10kb) Multiome | 325 | |
| chr17:19,866,833–19,868,282 | 85 bp | At TSS Multiome | 560 | |
| chr17:19,977,322–19,978,428 | 109.9 kb | Distal (>10kb) Multiome | 1017 | |
| chr17:19,992,824–19,993,272 | 125.1 kb | Distal (>10kb) Multiome | 455 | |
| chr17:20,008,666–20,010,100 | 141.4 kb | Distal (>10kb) Multiome | 646 | |
| chr17:20,155,600–20,156,828 | 288.1 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the ULK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.