This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for UFSP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UFSP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UFSP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:185,127,221–185,129,177 | 298.3 kb | Distal (>10kb) Multiome | 406 | |
| chr4:185,142,664–185,143,838 | 282.8 kb | Distal (>10kb) Multiome | 886 | |
| chr4:185,203,468–185,204,322 | 222.0 kb | Distal (>10kb) Multiome | 710 | |
| chr4:185,209,029–185,211,342 | 216.4 kb | Distal (>10kb) Multiome | 699 | |
| chr4:185,235,783–185,236,350 | 189.9 kb | Distal (>10kb) Multiome | 289 | |
| chr4:185,318,614–185,319,089 | 107.1 kb | Distal (>10kb) Multiome | 382 | |
| chr4:185,395,863–185,397,395 | 29.3 kb | Distal (>10kb) Multiome | 1140 | |
| chr4:185,425,371–185,426,547 | 95 bp | At TSS Multiome | 873 | |
| chr4:185,470,476–185,472,157 | 45.4 kb | Distal (>10kb) Multiome | 628 | |
| chr4:185,534,729–185,535,832 | 109.5 kb | Distal (>10kb) Multiome | 535 | |
| chr4:185,559,542–185,560,280 | 134.0 kb | Distal (>10kb) Multiome | 164 | |
| chr4:185,650,774–185,651,628 | 225.3 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the UFSP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.