The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for UCKL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UCKL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UCKL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,657,813–63,658,939 | 297.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:63,696,254–63,697,070 | 259.8 kb | Distal (>10kb) Multiome | 458 | |
| chr20:63,707,489–63,708,488 | 248.4 kb | Distal (>10kb) Multiome | 1008 | |
| chr20:63,737,573–63,741,470 | 216.7 kb | Distal (>10kb) Multiome | 1098 | |
| chr20:63,775,216–63,775,997 | 180.9 kb | Distal (>10kb) Multiome | 257 | |
| chr20:63,830,341–63,832,721 | 125.1 kb | Distal (>10kb) Multiome | 628 | |
| chr20:63,846,273–63,846,790 | 109.9 kb | Distal (>10kb) Multiome | 487 | |
| chr20:63,864,234–63,865,991 | 91.3 kb | Distal (>10kb) Multiome | 1158 | |
| chr20:63,894,341–63,895,764 | 61.4 kb | Distal (>10kb) Multiome | 791 | |
| chr20:63,938,191–63,939,815 | 17.7 kb | Distal (>10kb) Multiome | 287 | |
| chr20:63,939,918–63,942,008 | 14.8 kb | Distal (>10kb) Multiome | 496 | |
| chr20:63,949,150–63,949,442 | 6.9 kb | Proximal (<10kb) | 732 | |
| chr20:63,955,375–63,956,875 | 23 bp | At TSS Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 1.3 kb | Proximal (<10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 13.6 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 17.6 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 24.8 kb | Distal (>10kb) Multiome | 986 | |
| chr20:64,030,226–64,031,221 | 74.4 kb | Distal (>10kb) Multiome | 159 | |
| chr20:64,038,338–64,039,469 | 82.7 kb | Distal (>10kb) Multiome | 628 | |
| chr20:64,047,989–64,049,987 | 93.1 kb | Distal (>10kb) Multiome | 541 | |
| chr20:64,053,902–64,054,682 | 97.9 kb | Distal (>10kb) Multiome | 609 | |
| chr20:64,057,481–64,058,099 | 101.5 kb | Distal (>10kb) Multiome | 659 | |
| chr20:64,062,561–64,063,881 | 106.7 kb | Distal (>10kb) Multiome | 991 | |
| chr20:64,079,311–64,080,472 | 123.5 kb | Distal (>10kb) Multiome | 688 | |
| chr20:64,083,392–64,084,408 | 127.3 kb | Distal (>10kb) Multiome | 591 | |
| chr20:64,101,897–64,102,924 | 145.9 kb | Distal (>10kb) Multiome | 457 | |
| chr20:64,160,199–64,160,889 | 204.1 kb | Distal (>10kb) Multiome | 55 | |
| chr20:64,255,171–64,256,183 | 299.3 kb | Distal (>10kb) Multiome | 861 |
Genomic view of the UCKL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.