This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for UCK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UCK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UCK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:131,276,571–131,278,332 | 253.1 kb | Distal (>10kb) Multiome | 558 | |
| chr9:131,282,624–131,283,561 | 248.2 kb | Distal (>10kb) Multiome | 217 | |
| chr9:131,330,816–131,331,776 | 199.9 kb | Distal (>10kb) Multiome | 463 | |
| chr9:131,349,882–131,350,535 | 181.0 kb | Distal (>10kb) Multiome | 525 | |
| chr9:131,373,092–131,374,082 | 157.7 kb | Distal (>10kb) Multiome | 962 | |
| chr9:131,393,060–131,394,879 | 137.3 kb | Distal (>10kb) Multiome | 722 | |
| chr9:131,407,727–131,408,216 | 123.3 kb | Distal (>10kb) Multiome | 172 | |
| chr9:131,502,603–131,504,327 | 28.2 kb | Distal (>10kb) Multiome | 860 | |
| chr9:131,530,588–131,531,834 | 72 bp | At TSS Multiome | 635 | |
| chr9:131,739,378–131,740,405 | 208.8 kb | Distal (>10kb) Multiome | 513 | |
| chr9:131,807,487–131,807,943 | 276.5 kb | Distal (>10kb) Multiome | 104 |
Genomic view of the UCK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.