The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for UCHL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UCHL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UCHL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:41,019,694–41,020,610 | 236.6 kb | Distal (>10kb) Multiome | 145 | |
| chr4:41,213,575–41,215,619 | 42.3 kb | Distal (>10kb) Multiome | 729 | |
| chr4:41,215,788–41,216,995 | 40.4 kb | Distal (>10kb) Multiome | 821 | |
| chr4:41,256,257–41,258,246 | 30 bp | At TSS Multiome | 547 | |
| chr4:41,308,911–41,309,973 | 52.5 kb | Distal (>10kb) Multiome | 89 | |
| chr4:41,359,963–41,361,549 | 103.8 kb | Distal (>10kb) Multiome | 452 | |
| chr4:41,644,230–41,644,895 | 387.6 kb | Distal (>10kb) Multiome HiCAR | 292 |
Genomic view of the UCHL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.