This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for UBR7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBR7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBR7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:92,922,929–92,923,801 | 283.9 kb | Distal (>10kb) Multiome | 736 | |
| chr14:93,114,737–93,116,548 | 91.8 kb | Distal (>10kb) Multiome | 614 | |
| chr14:93,184,056–93,185,524 | 22.4 kb | Distal (>10kb) Multiome | 831 | |
| chr14:93,206,605–93,207,773 | 55 bp | At TSS Multiome | 809 | |
| chr14:93,332,195–93,333,678 | 125.8 kb | Distal (>10kb) Multiome | 770 | |
| chr14:93,422,034–93,422,544 | 215.1 kb | Distal (>10kb) Multiome | 15 | |
| chr14:93,430,263–93,431,562 | 223.4 kb | Distal (>10kb) Multiome | 232 |
Genomic view of the UBR7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.