This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBQLN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBQLN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBQLN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,536,923–83,539,150 | 169.3 kb | Distal (>10kb) Multiome | 773 | |
| chr9:83,622,459–83,623,894 | 84.8 kb | Distal (>10kb) Multiome | 774 | |
| chr9:83,630,907–83,631,624 | 76.7 kb | Distal (>10kb) Multiome | 194 | |
| chr9:83,706,859–83,708,822 | 803 bp | At TSS Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 109.8 kb | Distal (>10kb) Multiome | 350 | |
| chr9:83,920,675–83,922,066 | 213.4 kb | Distal (>10kb) Multiome | 895 | |
| chr9:83,956,086–83,957,142 | 248.8 kb | Distal (>10kb) Multiome | 869 | |
| chr9:83,979,201–83,981,658 | 272.6 kb | Distal (>10kb) Multiome | 1059 |
Genomic view of the UBQLN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.