Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:33,218,068–33,219,328 | 221.7 kb | Distal (>10kb) Multiome | 329 | |
| chr3:33,277,037–33,277,887 | 163.1 kb | Distal (>10kb) Multiome | 534 | |
| chr3:33,425,913–33,426,646 | 14.3 kb | Distal (>10kb) Multiome | 224 | |
| chr3:33,439,404–33,441,603 | 9 bp | At TSS Multiome | 1014 | |
| chr3:33,446,268–33,447,578 | 6.0 kb | Proximal (<10kb) Multiome | 160 | |
| chr3:33,658,997–33,659,827 | 218.7 kb | Distal (>10kb) Multiome | 599 | |
| chr3:33,717,274–33,718,580 | 277.6 kb | Distal (>10kb) Multiome | 885 | |
| chr3:33,787,069–33,787,693 | 346.9 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr3:33,798,073–33,799,435 | 358.3 kb | Distal (>10kb) Multiome HiCAR | 1044 |
Genomic view of the UBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.