UBOX5

U-box domain containing 5 | KIAA0860, RNF37, UIP5, Ubce7ip5

This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Member of: DE-5

Biological processes 16 terms

nuclear body (GO:0016604)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein polyubiquitination (GO:0000209)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-ubiquitin ligase activity (GO:0034450)ubiquitin-ubiquitin ligase activity (GO:0034450)ubiquitin-ubiquitin ligase activity (GO:0034450)

Expression (TPM)

TFs regulating UBOX5 0 TFs

Transcription factors with Perturb-seq knockdown data for UBOX5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBOX5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to UBOX5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBOX5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:2,872,329–2,874,047	286.3 kb	Distal (>10kb) Multiome	980
chr20:3,045,415–3,046,996	113.9 kb	Distal (>10kb) Multiome	999
chr20:3,071,569–3,072,466	87.7 kb	Distal (>10kb) Multiome	214
chr20:3,092,619–3,093,442	66.8 kb	Distal (>10kb) Multiome	180
chr20:3,159,566–3,160,153	33 bp	At TSS Multiome	1027
chr20:3,168,012–3,168,864	8.6 kb	Proximal (<10kb) Multiome	598
chr20:3,172,885–3,174,573	13.7 kb	Distal (>10kb) Multiome	1012
chr20:3,203,485–3,204,801	44.7 kb	Distal (>10kb) Multiome	952
chr20:3,218,394–3,218,992	58.8 kb	Distal (>10kb) Multiome	638
chr20:3,238,062–3,240,422	79.6 kb	Distal (>10kb) Multiome	714
chr20:3,407,081–3,408,415	247.9 kb	Distal (>10kb) Multiome	825
chr20:3,408,525–3,409,169	249.1 kb	Distal (>10kb) Multiome	453

Genome Browser

Genomic view of the UBOX5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.