Enables ubiquitin protein ligase activity. Involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBE3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:156,892,088–156,893,883 | 245.6 kb | Distal (>10kb) Multiome | 1026 | |
| chr7:156,948,934–156,950,397 | 189.3 kb | Distal (>10kb) Multiome | 895 | |
| chr7:157,003,648–157,004,372 | 134.8 kb | Distal (>10kb) Multiome | 255 | |
| chr7:157,009,113–157,012,019 | 128.1 kb | Distal (>10kb) Multiome HiCAR | 793 | |
| chr7:157,013,630–157,014,425 | 124.9 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr7:157,020,746–157,021,949 | 117.7 kb | Distal (>10kb) Multiome | 146 | |
| chr7:157,138,376–157,139,695 | 127 bp | At TSS Multiome | 863 | |
| chr7:157,273,400–157,274,009 | 134.8 kb | Distal (>10kb) Multiome | 578 | |
| chr7:157,279,203–157,279,779 | 140.6 kb | Distal (>10kb) Multiome | 291 | |
| chr7:157,310,335–157,311,049 | 171.7 kb | Distal (>10kb) Multiome | 312 | |
| chr7:157,336,012–157,338,044 | 198.0 kb | Distal (>10kb) Multiome | 778 |
Genomic view of the UBE3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.