This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for UBE2Z. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2Z upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2Z, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:48,610,274–48,610,853 | 297.6 kb | Distal (>10kb) Multiome | 450 | |
| chr17:48,671,728–48,672,690 | 235.9 kb | Distal (>10kb) Multiome | 409 | |
| chr17:48,678,104–48,678,743 | 229.9 kb | Distal (>10kb) Multiome | 453 | |
| chr17:48,718,468–48,719,563 | 189.5 kb | Distal (>10kb) Multiome | 164 | |
| chr17:48,719,708–48,720,337 | 188.4 kb | Distal (>10kb) Multiome | 181 | |
| chr17:48,722,219–48,723,762 | 185.5 kb | Distal (>10kb) Multiome | 220 | |
| chr17:48,728,286–48,729,570 | 179.5 kb | Distal (>10kb) Multiome | 376 | |
| chr17:48,816,754–48,817,592 | 91.2 kb | Distal (>10kb) Multiome | 589 | |
| chr17:48,830,670–48,831,519 | 77.3 kb | Distal (>10kb) Multiome | 838 | |
| chr17:48,891,910–48,893,540 | 15.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr17:48,907,825–48,909,317 | 90 bp | At TSS Multiome | 1011 | |
| chr17:48,944,483–48,945,203 | 36.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:48,995,124–48,997,874 | 89.0 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:49,013,253–49,014,714 | 105.6 kb | Distal (>10kb) Multiome | 480 | |
| chr17:49,022,149–49,022,993 | 114.2 kb | Distal (>10kb) Multiome | 306 | |
| chr17:49,031,811–49,032,444 | 123.9 kb | Distal (>10kb) Multiome | 423 | |
| chr17:49,035,641–49,036,299 | 127.6 kb | Distal (>10kb) Multiome | 338 | |
| chr17:49,191,794–49,193,465 | 284.4 kb | Distal (>10kb) Multiome | 1177 |
Genomic view of the UBE2Z locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.