Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for UBE2V1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2V1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2V1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:49,812,498–49,813,345 | 300.3 kb | Distal (>10kb) Multiome | 943 | |
| chr20:49,915,234–49,916,043 | 197.5 kb | Distal (>10kb) Multiome | 965 | |
| chr20:49,936,000–49,936,835 | 176.8 kb | Distal (>10kb) Multiome | 878 | |
| chr20:49,979,039–49,979,667 | 133.8 kb | Distal (>10kb) Multiome | 832 | |
| chr20:49,982,091–49,984,748 | 130.3 kb | Distal (>10kb) Multiome | 1116 | |
| chr20:49,997,468–49,998,291 | 115.4 kb | Distal (>10kb) Multiome | 80 | |
| chr20:50,012,403–50,013,184 | 100.3 kb | Distal (>10kb) Multiome | 334 | |
| chr20:50,112,672–50,113,319 | 13 bp | At TSS Multiome | 839 | |
| chr20:50,115,890–50,116,183 | 2.8 kb | Proximal (<10kb) | 634 | |
| chr20:50,153,404–50,154,338 | 40.7 kb | Distal (>10kb) Multiome | 1028 | |
| chr20:50,165,812–50,166,377 | 53.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr20:50,171,676–50,172,948 | 59.3 kb | Distal (>10kb) Multiome | 821 | |
| chr20:50,189,686–50,192,514 | 77.4 kb | Distal (>10kb) Multiome | 1125 | |
| chr20:50,194,979–50,195,626 | 82.3 kb | Distal (>10kb) Multiome | 299 | |
| chr20:50,321,165–50,321,654 | 208.4 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the UBE2V1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.