Transcription factors with Perturb-seq knockdown data for UBE2Q2P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2Q2P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2Q2P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,262,203–82,263,651 | 92.4 kb | Distal (>10kb) Multiome | 696 | |
| chr15:82,571,710–82,572,201 | 216.7 kb | Distal (>10kb) Multiome | 194 | |
| chr15:82,647,462–82,648,736 | 293.0 kb | Distal (>10kb) Multiome | 511 | |
| chr15:82,679,753–82,681,281 | 325.4 kb | Distal (>10kb) Multiome | 495 | |
| chr15:82,708,766–82,710,416 | 354.6 kb | Distal (>10kb) Multiome | 725 |
Genomic view of the UBE2Q2P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.