The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for UBE2L6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2L6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2L6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,277,829–57,278,561 | 289.6 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,310,924–57,312,111 | 256.1 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 242.7 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 231.9 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 221.9 kb | Distal (>10kb) Multiome HiCAR | 241 | |
| chr11:57,349,624–57,350,269 | 217.7 kb | Distal (>10kb) Multiome HiCAR | 357 | |
| chr11:57,426,113–57,427,448 | 140.6 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 110.2 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 106.3 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,482,336–57,483,518 | 84.5 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 74.0 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 67.9 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 53.2 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 36.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,562,709–57,562,853 | 4.8 kb | Proximal (<10kb) | 17 | |
| chr11:57,567,377–57,568,664 | 460 bp | At TSS Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 30.4 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 71.9 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 77.3 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr11:57,656,843–57,658,231 | 89.9 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 100.1 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 144.6 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 173.8 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 194.1 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 211.0 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 214.0 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the UBE2L6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.