Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBE2E2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2E2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2E2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:23,198,597–23,199,004 | 4.2 kb | Proximal (<10kb) | 21 | |
| chr3:23,199,300–23,199,995 | 3.2 kb | Proximal (<10kb) | 33 | |
| chr3:23,202,243–23,204,183 | 66 bp | At TSS Multiome | 694 | |
| chr3:23,274,589–23,276,263 | 72.1 kb | Distal (>10kb) Multiome | 249 | |
| chr3:23,805,437–23,807,461 | 602.7 kb | Distal (>10kb) Multiome HiCAR | 636 |
Genomic view of the UBE2E2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.