Enables RNA binding activity. Involved in binding activity of sperm to zona pellucida; positive regulation of stress granule assembly; and stress granule assembly. Acts upstream of or within hematopoietic stem cell homeostasis. Part of PcG protein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBAP2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBAP2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBAP2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,922,213–153,923,779 | 297.9 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 274.3 kb | Distal (>10kb) Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 262.3 kb | Distal (>10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 257.3 kb | Distal (>10kb) Multiome | 798 | |
| chr1:153,967,147–153,968,324 | 253.3 kb | Distal (>10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 243.3 kb | Distal (>10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 234.5 kb | Distal (>10kb) Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 230.2 kb | Distal (>10kb) Multiome | 950 | |
| chr1:154,182,339–154,183,774 | 37.6 kb | Distal (>10kb) Multiome | 934 | |
| chr1:154,220,079–154,221,864 | 194 bp | At TSS Multiome | 1071 | |
| chr1:154,272,082–154,272,847 | 51.5 kb | Distal (>10kb) Multiome | 834 | |
| chr1:154,324,640–154,326,731 | 103.9 kb | Distal (>10kb) Multiome | 685 | |
| chr1:154,328,267–154,328,890 | 107.7 kb | Distal (>10kb) Multiome | 261 | |
| chr1:154,352,626–154,353,487 | 132.2 kb | Distal (>10kb) Multiome | 466 | |
| chr1:154,404,987–154,406,067 | 184.5 kb | Distal (>10kb) Multiome | 731 | |
| chr1:154,489,011–154,489,730 | 268.5 kb | Distal (>10kb) Multiome | 82 | |
| chr1:154,493,110–154,493,579 | 272.4 kb | Distal (>10kb) Multiome | 134 | |
| chr1:154,501,716–154,502,717 | 281.7 kb | Distal (>10kb) Multiome | 212 |
Genomic view of the UBAP2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.