Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TXNDC16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXNDC16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXNDC16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:52,267,300–52,269,041 | 284.7 kb | Distal (>10kb) Multiome | 262 | |
| chr14:52,313,824–52,315,725 | 238.2 kb | Distal (>10kb) Multiome | 457 | |
| chr14:52,551,688–52,554,284 | 198 bp | At TSS Multiome | 899 | |
| chr14:52,694,713–52,696,105 | 143.2 kb | Distal (>10kb) Multiome | 749 | |
| chr14:52,706,745–52,707,707 | 154.6 kb | Distal (>10kb) Multiome | 713 | |
| chr14:52,729,614–52,730,927 | 177.6 kb | Distal (>10kb) Multiome | 803 | |
| chr14:52,790,881–52,792,384 | 239.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:52,827,263–52,828,172 | 275.1 kb | Distal (>10kb) Multiome | 103 | |
| chr14:52,835,079–52,835,883 | 282.9 kb | Distal (>10kb) Multiome | 369 |
Genomic view of the TXNDC16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.