This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for TXLNG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXLNG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXLNG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:16,719,154–16,719,979 | 66.9 kb | Distal (>10kb) Multiome | 716 | |
| chrX:16,771,090–16,772,164 | 14.8 kb | Distal (>10kb) Multiome | 626 | |
| chrX:16,786,080–16,787,269 | 121 bp | At TSS Multiome | 646 | |
| chrX:16,869,468–16,871,503 | 84.0 kb | Distal (>10kb) Multiome | 687 | |
| chrX:16,946,195–16,947,346 | 160.2 kb | Distal (>10kb) Multiome | 329 | |
| chrX:17,007,183–17,007,806 | 221.0 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the TXLNG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.