Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of macromolecule biosynthetic process; positive regulation of type II interferon-mediated signaling pathway; and protein autophosphorylation. Located in cytosol; nuclear lumen; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TXK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TXK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TXK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:47,836,414–47,838,176 | 243.3 kb | Distal (>10kb) Multiome | 604 | |
| chr4:47,913,703–47,915,119 | 165.5 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr4:47,926,660–47,927,239 | 153.3 kb | Distal (>10kb) Multiome | 243 | |
| chr4:48,015,887–48,017,756 | 63.5 kb | Distal (>10kb) Multiome | 714 | |
| chr4:48,071,082–48,071,611 | 8.6 kb | Proximal (<10kb) | 60 | |
| chr4:48,079,945–48,080,353 | at TSS | At TSS | 197 | |
| chr4:48,087,220–48,087,429 | 7.0 kb | Proximal (<10kb) | 50 | |
| chr4:48,126,799–48,128,119 | 47.7 kb | Distal (>10kb) Multiome | 526 | |
| chr4:48,268,963–48,270,705 | 189.7 kb | Distal (>10kb) Multiome | 781 | |
| chr4:48,340,361–48,342,666 | 261.2 kb | Distal (>10kb) Multiome | 962 |
Genomic view of the TXK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.