Enables transforming growth factor beta binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of cytokine production; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TWSG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TWSG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TWSG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:9,102,098–9,103,261 | 232.2 kb | Distal (>10kb) Multiome | 815 | |
| chr18:9,135,781–9,137,908 | 197.5 kb | Distal (>10kb) Multiome | 1018 | |
| chr18:9,264,819–9,265,280 | 69.8 kb | Distal (>10kb) Multiome | 49 | |
| chr18:9,333,728–9,335,352 | 215 bp | At TSS Multiome | 738 | |
| chr18:9,474,512–9,476,246 | 140.5 kb | Distal (>10kb) Multiome | 971 | |
| chr18:9,495,937–9,496,497 | 161.4 kb | Distal (>10kb) Multiome | 78 | |
| chr18:9,613,721–9,615,403 | 280.1 kb | Distal (>10kb) Multiome | 740 |
Genomic view of the TWSG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.