TUBGCP2

tubulin gamma complex component 2 | ALP4, GCP2, SPBC97, Spc97p, hGCP2

Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Involved in brain development and neuron migration. Located in centrosome; ciliary basal body; and nucleoplasm. Implicated in pachygyria, microcephaly, developmental delay, and dysmorphic facies, with or without seizures. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-12

Biological processes 27 terms

brain development (GO:0007420)centrosome (GO:0005813)centrosome (GO:0005813)cytoplasmic microtubule (GO:0005881)cytoplasmic microtubule organization (GO:0031122)cytosol (GO:0005829)gamma-tubulin binding (GO:0043015)gamma-tubulin binding (GO:0043015)gamma-tubulin complex (GO:0000930)meiotic cell cycle (GO:0051321)membrane (GO:0016020)microtubule cytoskeleton organization (GO:0000226)microtubule minus-end binding (GO:0051011)microtubule nucleation (GO:0007020)microtubule nucleation (GO:0007020)microtubule nucleation (GO:0007020)microtubule nucleation (GO:0007020)microtubule organizing center (GO:0005815)microtubule organizing center (GO:0005815)microtubule organizing center (GO:0005815)microtubule organizing center (GO:0005815)mitotic cell cycle (GO:0000278)neuron migration (GO:0001764)protein binding (GO:0005515)protein-containing complex assembly (GO:0065003)spindle assembly (GO:0051225)spindle pole (GO:0000922)

Expression (TPM)

TFs regulating TUBGCP2 0 TFs

Transcription factors with Perturb-seq knockdown data for TUBGCP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBGCP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TUBGCP2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBGCP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:133,087,734–133,088,838	221.2 kb	Distal (>10kb) Multiome	273
chr10:133,143,227–133,144,444	165.1 kb	Distal (>10kb) Multiome	346
chr10:133,159,602–133,160,521	148.9 kb	Distal (>10kb) Multiome	198
chr10:133,229,278–133,231,486	78.9 kb	Distal (>10kb) Multiome	253
chr10:133,231,897–133,232,673	76.8 kb	Distal (>10kb) Multiome	75
chr10:133,235,225–133,235,826	73.4 kb	Distal (>10kb) Multiome	122
chr10:133,236,052–133,238,686	71.4 kb	Distal (>10kb) Multiome	361
chr10:133,245,223–133,246,111	63.3 kb	Distal (>10kb) Multiome	265
chr10:133,247,041–133,247,539	61.9 kb	Distal (>10kb) Multiome	168
chr10:133,257,420–133,258,249	51.3 kb	Distal (>10kb) Multiome	384
chr10:133,261,265–133,262,426	47.1 kb	Distal (>10kb) Multiome	421
chr10:133,276,420–133,277,460	32.2 kb	Distal (>10kb) Multiome	216
chr10:133,307,807–133,309,623	30 bp	At TSS Multiome	785
chr10:133,313,908–133,314,101	5.0 kb	Proximal (<10kb)	61
chr10:133,318,523–133,319,017	9.7 kb	Proximal (<10kb) Multiome	567
chr10:133,324,203–133,325,065	15.4 kb	Distal (>10kb) Multiome	243
chr10:133,329,452–133,330,224	20.8 kb	Distal (>10kb) Multiome	471
chr10:133,357,077–133,358,582	48.8 kb	Distal (>10kb) Multiome	649
chr10:133,373,095–133,373,842	64.3 kb	Distal (>10kb) Multiome	589
chr10:133,377,993–133,380,099	70.1 kb	Distal (>10kb) Multiome	714
chr10:133,393,908–133,394,705	85.0 kb	Distal (>10kb) Multiome	959

Genome Browser

Genomic view of the TUBGCP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.