This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for TTLL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTLL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTLL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:75,419,070–75,419,695 | 241.5 kb | Distal (>10kb) Multiome | 358 | |
| chr14:75,427,222–75,428,490 | 233.0 kb | Distal (>10kb) Multiome | 640 | |
| chr14:75,452,945–75,453,577 | 207.7 kb | Distal (>10kb) Multiome | 408 | |
| chr14:75,577,727–75,579,221 | 82.4 kb | Distal (>10kb) Multiome | 646 | |
| chr14:75,604,930–75,606,141 | 55.5 kb | Distal (>10kb) Multiome | 195 | |
| chr14:75,646,886–75,647,914 | 13.5 kb | Distal (>10kb) Multiome | 156 | |
| chr14:75,654,222–75,654,432 | 6.6 kb | Proximal (<10kb) | 253 | |
| chr14:75,660,453–75,661,746 | 125 bp | At TSS Multiome | 786 | |
| chr14:75,711,559–75,712,330 | 51.0 kb | Distal (>10kb) Multiome | 434 | |
| chr14:75,972,579–75,973,063 | 311.8 kb | Distal (>10kb) Multiome HiCAR | 56 | |
| chr14:75,982,219–75,983,158 | 321.6 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr14:75,985,670–75,986,242 | 324.9 kb | Distal (>10kb) Multiome HiCAR | 373 |
Genomic view of the TTLL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.