This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TTF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:116,909,571–116,911,117 | 150.3 kb | Distal (>10kb) Multiome | 645 | |
| chr1:117,059,404–117,060,970 | 234 bp | At TSS Multiome | 909 | |
| chr1:117,061,072–117,061,187 | 711 bp | At TSS | 33 | |
| chr1:117,067,876–117,068,066 | 7.5 kb | Proximal (<10kb) | 148 | |
| chr1:117,121,317–117,122,916 | 61.6 kb | Distal (>10kb) Multiome | 747 | |
| chr1:117,268,677–117,269,503 | 208.9 kb | Distal (>10kb) Multiome | 284 | |
| chr1:117,346,297–117,347,531 | 286.4 kb | Distal (>10kb) Multiome | 215 |
Genomic view of the TTF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.