Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC9-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC9-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC9-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:70,359,242–70,360,086 | 281.6 kb | Distal (>10kb) Multiome | 1022 | |
| chr14:70,378,111–70,379,006 | 262.7 kb | Distal (>10kb) Multiome | 31 | |
| chr14:70,416,744–70,417,234 | 224.3 kb | Distal (>10kb) Multiome | 527 | |
| chr14:70,600,414–70,601,212 | 40.5 kb | Distal (>10kb) Multiome | 519 | |
| chr14:70,641,239–70,642,585 | 453 bp | At TSS Multiome | 486 | |
| chr14:70,646,773–70,647,010 | 5.5 kb | Proximal (<10kb) | 34 | |
| chr14:70,716,516–70,717,866 | 75.8 kb | Distal (>10kb) Multiome | 256 | |
| chr14:70,753,481–70,754,035 | 112.4 kb | Distal (>10kb) Multiome | 262 | |
| chr14:70,808,217–70,810,598 | 168.4 kb | Distal (>10kb) Multiome | 697 | |
| chr14:70,817,332–70,818,017 | 176.6 kb | Distal (>10kb) Multiome | 483 | |
| chr14:70,821,689–70,823,208 | 181.5 kb | Distal (>10kb) Multiome | 559 | |
| chr14:70,907,022–70,908,784 | 266.2 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the TTC9-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.