This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for TTC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:54,474,500–54,475,180 | 240.9 kb | Distal (>10kb) Multiome | 231 | |
| chr1:54,487,606–54,488,753 | 227.5 kb | Distal (>10kb) Multiome | 766 | |
| chr1:54,488,856–54,491,244 | 226.3 kb | Distal (>10kb) Multiome | 749 | |
| chr1:54,541,930–54,543,207 | 173.4 kb | Distal (>10kb) Multiome | 769 | |
| chr1:54,715,256–54,716,151 | 70 bp | At TSS Multiome | 918 | |
| chr1:54,764,040–54,765,112 | 48.8 kb | Distal (>10kb) Multiome | 791 | |
| chr1:54,775,004–54,775,454 | 59.4 kb | Distal (>10kb) Multiome | 135 | |
| chr1:54,781,116–54,781,700 | 65.5 kb | Distal (>10kb) Multiome | 190 | |
| chr1:54,800,637–54,801,431 | 85.3 kb | Distal (>10kb) Multiome | 286 | |
| chr1:54,886,423–54,888,260 | 171.4 kb | Distal (>10kb) Multiome | 867 | |
| chr1:54,950,380–54,951,143 | 234.9 kb | Distal (>10kb) Multiome | 459 | |
| chr1:54,980,478–54,981,190 | 264.9 kb | Distal (>10kb) Multiome | 185 | |
| chr1:54,996,310–54,996,725 | 280.8 kb | Distal (>10kb) Multiome | 355 |
Genomic view of the TTC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.