Involved in actin filament polymerization and cilium organization. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:43,074,508–43,075,922 | 283.7 kb | Distal (>10kb) Multiome | 328 | |
| chr11:43,118,911–43,119,871 | 239.5 kb | Distal (>10kb) Multiome | 87 | |
| chr11:43,130,136–43,131,188 | 228.2 kb | Distal (>10kb) Multiome | 99 | |
| chr11:43,311,481–43,312,563 | 47.0 kb | Distal (>10kb) Multiome | 920 | |
| chr11:43,351,545–43,351,711 | 7.2 kb | Proximal (<10kb) | 17 | |
| chr11:43,358,425–43,359,827 | 34 bp | At TSS Multiome | 931 | |
| chr11:43,576,840–43,577,310 | 218.2 kb | Distal (>10kb) Multiome | 464 | |
| chr11:43,578,930–43,580,292 | 220.4 kb | Distal (>10kb) Multiome | 326 | |
| chr11:43,643,882–43,644,534 | 285.2 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the TTC17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.