The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for TSR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,182,249–54,183,769 | 257.0 kb | Distal (>10kb) Multiome | 570 | |
| chrX:54,357,469–54,359,170 | 82.3 kb | Distal (>10kb) Multiome | 438 | |
| chrX:54,388,044–54,388,641 | 52.0 kb | Distal (>10kb) Multiome | 49 | |
| chrX:54,439,963–54,440,865 | 42 bp | At TSS Multiome | 587 | |
| chrX:54,495,407–54,496,558 | 55.7 kb | Distal (>10kb) Multiome | 248 | |
| chrX:54,529,579–54,530,565 | 89.7 kb | Distal (>10kb) Multiome | 641 | |
| chrX:54,639,123–54,640,128 | 199.3 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the TSR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.