TSPYL2

TSPY like 2 | CDA1, CINAP, CTCL, DENTT, HRIHFB2216, SE20-4, TSPX

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Member of: DE-5 DE-5.10

Biological processes 17 terms

chromatin (GO:0000785)chromatin binding (GO:0003682)cytoplasm (GO:0005737)histone binding (GO:0042393)negative regulation of DNA replication (GO:0008156)negative regulation of cell cycle (GO:0045786)negative regulation of cell growth (GO:0030308)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleosome assembly (GO:0006334)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)rDNA binding (GO:0000182)regulation of protein kinase activity (GO:0045859)regulation of signal transduction (GO:0009966)

Expression (TPM)

TFs regulating TSPYL2 0 TFs

Transcription factors with Perturb-seq knockdown data for TSPYL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPYL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TSPYL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPYL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chrX:52,920,527–52,921,722	161.3 kb	Distal (>10kb) Multiome	769
chrX:52,934,457–52,935,577	147.4 kb	Distal (>10kb) Multiome	844
chrX:52,995,188–52,996,036	86.7 kb	Distal (>10kb) Multiome	504
chrX:53,048,205–53,048,827	33.8 kb	Distal (>10kb) Multiome	184
chrX:53,081,783–53,082,862	145 bp	At TSS Multiome	557
chrX:53,088,446–53,088,904	6.4 kb	Proximal (<10kb) Multiome	204
chrX:53,089,356–53,089,519	7.0 kb	Proximal (<10kb)	93
chrX:53,093,602–53,094,629	11.7 kb	Distal (>10kb) Multiome	585
chrX:53,224,805–53,225,756	143.0 kb	Distal (>10kb) Multiome	825

Genome Browser

Genomic view of the TSPYL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.