The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for TSPAN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:115,089,065–115,090,565 | 164 bp | At TSS Multiome | 328 | |
| chr1:115,138,782–115,139,396 | 49.6 kb | Distal (>10kb) Multiome | 289 | |
| chr1:115,337,283–115,338,935 | 248.8 kb | Distal (>10kb) Multiome | 376 | |
| chr1:115,536,244–115,536,776 | 446.9 kb | Distal (>10kb) Multiome HiCAR | 29 | |
| chr1:115,593,347–115,594,339 | 504.3 kb | Distal (>10kb) Multiome HiCAR | 81 |
Genomic view of the TSPAN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.