Enables enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TSPAN14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSPAN14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSPAN14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:80,204,736–80,206,157 | 248.7 kb | Distal (>10kb) Multiome | 830 | |
| chr10:80,207,076–80,207,999 | 246.8 kb | Distal (>10kb) Multiome | 466 | |
| chr10:80,265,707–80,266,498 | 188.2 kb | Distal (>10kb) Multiome | 166 | |
| chr10:80,356,265–80,357,947 | 97.4 kb | Distal (>10kb) Multiome | 316 | |
| chr10:80,407,698–80,409,441 | 45.8 kb | Distal (>10kb) Multiome | 766 | |
| chr10:80,444,724–80,445,182 | 9.1 kb | Proximal (<10kb) | 345 | |
| chr10:80,453,293–80,455,470 | 200 bp | At TSS Multiome | 715 | |
| chr10:80,457,956–80,458,205 | 3.6 kb | Proximal (<10kb) | 68 | |
| chr10:80,459,058–80,459,580 | 4.7 kb | Proximal (<10kb) | 345 | |
| chr10:80,460,762–80,461,239 | 6.6 kb | Proximal (<10kb) Multiome | 249 | |
| chr10:80,464,428–80,465,474 | 10.5 kb | Distal (>10kb) Multiome | 372 | |
| chr10:80,537,302–80,538,301 | 83.6 kb | Distal (>10kb) Multiome | 133 | |
| chr10:80,662,717–80,663,273 | 208.6 kb | Distal (>10kb) Multiome | 337 | |
| chr10:80,699,208–80,700,299 | 245.4 kb | Distal (>10kb) Multiome | 353 | |
| chr10:80,736,492–80,737,557 | 282.7 kb | Distal (>10kb) Multiome | 70 | |
| chr10:80,738,592–80,739,274 | 284.6 kb | Distal (>10kb) Multiome | 109 | |
| chr10:80,739,962–80,741,090 | 286.1 kb | Distal (>10kb) Multiome | 285 |
Genomic view of the TSPAN14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.