This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TSNAX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSNAX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSNAX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:231,240,746–231,241,633 | 287.4 kb | Distal (>10kb) Multiome | 834 | |
| chr1:231,337,024–231,338,750 | 190.6 kb | Distal (>10kb) Multiome | 881 | |
| chr1:231,420,882–231,422,905 | 106.3 kb | Distal (>10kb) Multiome | 956 | |
| chr1:231,528,042–231,528,983 | 150 bp | At TSS Multiome | 873 | |
| chr1:231,626,385–231,627,805 | 98.8 kb | Distal (>10kb) Multiome | 776 | |
| chr1:231,806,520–231,806,998 | 278.2 kb | Distal (>10kb) Multiome | 204 |
Genomic view of the TSNAX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.