TSC22D1
TSC22 domain family member 1 | MGC17597, TSC22, TGFB1I4

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Member of: DE-3 DE-3.37
Biological processes 23 terms
cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)identical protein binding (GO:0042802)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of apoptotic process (GO:0043066)negative regulation of hematopoietic stem cell proliferation (GO:1902034)negative regulation of programmed cell death (GO:0043069)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of apoptotic process (GO:0043065)positive regulation of cell population proliferation (GO:0008284)positive regulation of programmed cell death (GO:0043068)positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)transcription by RNA polymerase II (GO:0006366)transcription coactivator activity (GO:0003713)
Expression (TPM)
TSC22D1 — as a Regulated Gene

TFs regulating TSC22D1 0 TFs

Transcription factors with Perturb-seq knockdown data for TSC22D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSC22D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TSC22D1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSC22D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr13:43,878,973–43,880,447 557.6 kb Distal (>10kb) Multiome HiCAR 799
chr13:44,078,845–44,079,278 358.1 kb Distal (>10kb) Multiome HiCAR 56
chr13:44,108,414–44,108,986 328.5 kb Distal (>10kb) Multiome HiCAR 389
chr13:44,141,321–44,142,793 295.2 kb Distal (>10kb) Multiome HiCAR 822
chr13:44,305,024–44,306,307 131.8 kb Distal (>10kb) Multiome 262
chr13:44,373,369–44,374,512 63.1 kb Distal (>10kb) Multiome 294
chr13:44,396,454–44,397,617 40.2 kb Distal (>10kb) Multiome 310
chr13:44,434,997–44,435,965 1.9 kb Proximal (<10kb) Multiome 550
chr13:44,436,531–44,437,380 256 bp At TSS Multiome 600
chr13:44,437,859–44,437,985 1.0 kb Proximal (<10kb) 61
chr13:44,575,739–44,578,394 140.3 kb Distal (>10kb) Multiome 917
chr13:44,591,254–44,591,928 154.3 kb Distal (>10kb) Multiome 117
chr13:44,648,814–44,649,412 211.9 kb Distal (>10kb) Multiome 190

Genome Browser

Genomic view of the TSC22D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr13:43,868,973 – 44,659,412
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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