TRUB2
TruB pseudouridine synthase family member 2 | CLONE24922

Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]

Biological processes 26 terms
RNA binding (GO:0003723)RNA binding (GO:0003723)RNA modification (GO:0009451)RNA processing (GO:0006396)mRNA modification (GO:0016556)mRNA pseudouridine synthesis (GO:1990481)mRNA pseudouridine synthesis (GO:1990481)mRNA pseudouridine synthesis (GO:1990481)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial tRNA pseudouridine synthesis (GO:0070902)mitochondrion (GO:0005739)mitochondrion (GO:0005739)positive regulation of mitochondrial translation (GO:0070131)positive regulation of mitochondrial translation (GO:0070131)pseudouridine synthase activity (GO:0009982)pseudouridine synthase activity (GO:0009982)pseudouridine synthase activity (GO:0009982)pseudouridine synthase activity (GO:0009982)pseudouridine synthesis (GO:0001522)ribonucleoprotein granule (GO:0035770)tRNA pseudouridine(55) synthase activity (GO:0160148)tRNA pseudouridine(55) synthase activity (GO:0160148)
Expression (TPM)
TRUB2 — as a Regulated Gene

TFs regulating TRUB2 0 TFs

Transcription factors with Perturb-seq knockdown data for TRUB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRUB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRUB2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRUB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr9:128,033,544–128,034,106 288.5 kb Distal (>10kb) Multiome 69
chr9:128,034,940–128,035,527 287.1 kb Distal (>10kb) Multiome 480
chr9:128,066,577–128,068,774 255.0 kb Distal (>10kb) Multiome 874
chr9:128,097,872–128,098,910 224.0 kb Distal (>10kb) Multiome 712
chr9:128,117,658–128,118,328 204.6 kb Distal (>10kb) Multiome 640
chr9:128,127,314–128,128,793 194.1 kb Distal (>10kb) Multiome 899
chr9:128,159,371–128,160,928 162.3 kb Distal (>10kb) Multiome 824
chr9:128,191,300–128,192,050 130.8 kb Distal (>10kb) Multiome 865
chr9:128,203,004–128,204,704 118.0 kb Distal (>10kb) Multiome 690
chr9:128,218,656–128,219,107 103.5 kb Distal (>10kb) Multiome 410
chr9:128,250,012–128,251,099 71.9 kb Distal (>10kb) Multiome 353
chr9:128,275,636–128,276,535 46.4 kb Distal (>10kb) Multiome 728
chr9:128,322,183–128,322,933 189 bp At TSS Multiome 962
chr9:128,340,070–128,341,161 18.1 kb Distal (>10kb) Multiome 803
chr9:128,364,858–128,365,437 42.7 kb Distal (>10kb) Multiome 442
chr9:128,420,259–128,421,260 98.3 kb Distal (>10kb) Multiome 701
chr9:128,455,721–128,456,522 133.7 kb Distal (>10kb) Multiome 684
chr9:128,504,482–128,505,188 182.3 kb Distal (>10kb) Multiome 766
chr9:128,552,006–128,553,125 230.1 kb Distal (>10kb) Multiome 839

Genome Browser

Genomic view of the TRUB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr9:128,023,544 – 128,563,125
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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