Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRPV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRPV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRPV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,529,956–3,530,848 | 79.0 kb | Distal (>10kb) Multiome | 320 | |
| chr17:3,535,341–3,536,205 | 73.8 kb | Distal (>10kb) Multiome | 356 | |
| chr17:3,546,350–3,546,812 | 62.8 kb | Distal (>10kb) Multiome | 106 | |
| chr17:3,635,650–3,637,225 | 27.0 kb | Distal (>10kb) Multiome | 866 | |
| chr17:3,667,393–3,669,475 | 59.2 kb | Distal (>10kb) Multiome | 949 | |
| chr17:3,723,432–3,724,429 | 114.4 kb | Distal (>10kb) Multiome | 865 | |
| chr17:3,754,197–3,755,835 | 145.5 kb | Distal (>10kb) Multiome | 396 | |
| chr17:3,845,518–3,846,549 | 236.9 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 283.9 kb | Distal (>10kb) Multiome | 716 |
Genomic view of the TRPV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.