This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for TRMT6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:5,750,092–5,750,988 | 200.0 kb | Distal (>10kb) Multiome | 748 | |
| chr20:5,911,112–5,912,073 | 38.9 kb | Distal (>10kb) Multiome | 998 | |
| chr20:5,950,060–5,951,226 | 69 bp | At TSS Multiome | 919 | |
| chr20:6,005,701–6,006,981 | 55.5 kb | Distal (>10kb) Multiome | 999 | |
| chr20:6,051,939–6,053,048 | 102.0 kb | Distal (>10kb) Multiome | 308 | |
| chr20:6,058,492–6,059,323 | 108.4 kb | Distal (>10kb) Multiome | 284 | |
| chr20:6,122,311–6,123,822 | 172.6 kb | Distal (>10kb) Multiome | 952 |
Genomic view of the TRMT6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.