This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for TRMT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,825,565–12,826,186 | 290.9 kb | Distal (>10kb) Multiome | 436 | |
| chr19:12,832,484–12,833,101 | 284.1 kb | Distal (>10kb) Multiome | 970 | |
| chr19:12,833,638–12,834,477 | 282.8 kb | Distal (>10kb) Multiome | 310 | |
| chr19:12,838,114–12,838,869 | 278.3 kb | Distal (>10kb) Multiome | 377 | |
| chr19:12,840,071–12,841,485 | 275.9 kb | Distal (>10kb) Multiome | 391 | |
| chr19:12,847,633–12,848,090 | 269.0 kb | Distal (>10kb) Multiome | 535 | |
| chr19:12,867,327–12,868,022 | 249.1 kb | Distal (>10kb) Multiome | 315 | |
| chr19:12,872,968–12,873,990 | 243.4 kb | Distal (>10kb) Multiome | 263 | |
| chr19:12,880,834–12,881,875 | 235.2 kb | Distal (>10kb) Multiome | 656 | |
| chr19:12,884,836–12,886,381 | 231.3 kb | Distal (>10kb) Multiome | 717 | |
| chr19:12,890,614–12,891,603 | 225.7 kb | Distal (>10kb) Multiome | 841 | |
| chr19:12,913,054–12,913,584 | 203.4 kb | Distal (>10kb) Multiome | 373 | |
| chr19:12,919,018–12,919,719 | 197.3 kb | Distal (>10kb) Multiome | 732 | |
| chr19:12,933,441–12,934,086 | 183.0 kb | Distal (>10kb) Multiome | 789 | |
| chr19:12,937,426–12,939,166 | 178.3 kb | Distal (>10kb) Multiome | 943 | |
| chr19:12,945,275–12,946,647 | 170.8 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:12,956,801–12,957,360 | 159.5 kb | Distal (>10kb) Multiome | 747 | |
| chr19:12,964,998–12,965,862 | 151.3 kb | Distal (>10kb) Multiome | 733 | |
| chr19:12,983,506–12,983,997 | 133.1 kb | Distal (>10kb) Multiome HiCAR | 688 | |
| chr19:13,051,485–13,052,169 | 64.9 kb | Distal (>10kb) Multiome | 649 | |
| chr19:13,061,195–13,061,672 | 55.2 kb | Distal (>10kb) Multiome | 544 | |
| chr19:13,069,469–13,070,306 | 46.9 kb | Distal (>10kb) Multiome | 334 | |
| chr19:13,093,620–13,094,260 | 22.8 kb | Distal (>10kb) Multiome | 411 | |
| chr19:13,095,079–13,096,870 | 21.3 kb | Distal (>10kb) Multiome | 501 | |
| chr19:13,102,495–13,103,074 | 13.9 kb | Distal (>10kb) Multiome | 606 | |
| chr19:13,116,411–13,117,080 | 6 bp | At TSS Multiome | 812 | |
| chr19:13,117,979–13,119,416 | 1.5 kb | Proximal (<10kb) Multiome | 699 | |
| chr19:13,149,468–13,156,577 | 33.6 kb | Distal (>10kb) Multiome | 1333 | |
| chr19:13,162,579–13,165,523 | 48.0 kb | Distal (>10kb) Multiome | 1112 | |
| chr19:13,167,359–13,168,023 | 51.0 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the TRMT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.